Principles and Models of Biological TransportFocus, Organization, and Content This book, like the first edition, deals with the mass transport processes that take place in living systems, with a focus on the normal behavior of eukaryotic cells and the - ganisms they constitute, in their normal physiological environment. As a consequence of this focus, the structure and content of the book differ from those of traditional transport texts. We do not start with the engineering principles of mass transport (which are well presented elsewhere) and then seek biological applications of these principles; rather, we begin with the biological processes themselves, and then - velop the models and analytical tools that are needed to describe them. This approach has several consequences. First of all, it drives the content of the text in a direction distinctively different from conventional transport texts. This is - cause the tools and models needed to describe complex biological processes are often different from those employed to describe more well-characterized inanimate systems. Many biological processes must still be described phenomenologically, using me- odologies like nonequilibrium thermodynamics. Simple electrical analogs employing a paucity of parameters can be more useful for characterization and prediction than complex theories based on the behavior of more well-defined systems on a laboratory bench. By allowing the biology to drive the choice of analysis tools and models, the latter are consistently presented in the context of real biological systems, and analysis and biology are interwoven throughout. |
Contents
1 | |
FRIEDMAN102pdf | 28 |
FRIEDMAN103pdf | 67 |
FRIEDMAN104pdf | 110 |
FRIEDMAN105pdf | 185 |
FRIEDMAN106pdf | 225 |
FRIEDMAN107pdf | 265 |
FRIEDMAN108pdf | 299 |
FRIEDMAN109pdf | 329 |
FRIEDMAN110pdf | 390 |
FRIEDMAN111pdf | 447 |
FRIEDMAN112pdf | 485 |
497 | |
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Common terms and phrases
action potential active transport apical assumed ATPase axon basolateral bilayer binding sites blood bound brane calcium capillary carrier cation cell membrane Chapter charge chemical potential chloride compartment concentration conductance convection cosolute cotransport coupling cross the membrane cytoplasm cytosol depends depolarization described diffusion coefficient driving force effect electrical electrochemical potential energy epithelial epithelium equilibrium exchange fluid fraction free diffusion function gate glucose gradient inactivation increases interactions intracellular ionic kinesin kinetics lipid measured mechanism membrane potential molecules muscle Nernst potential nerve neuron nonelectrolyte nonequilibrium thermodynamics osmotic pressure oxygen oxygen tension passive pathways permeability Phase pore potassium channels potential difference pressure difference protein pump radius rate constants ratio reaction receptor red cell reflection coefficient release shown in Figure sodium channel solute flux solvent species substrate subunits symport tion tissue trans transition transmembrane transport processes transport systems tubule vesicles voltage zero