The Kinetics of Muscle Contraction

A. F. Huxley A. V. Hill actin actin-myosin actomyosin amplitude applied ATP concentration ATPase activity attached bridges attached cross-bridges biochemical Ca++ contractile contraction cross-bridge cycle detachment dissociation distributions effect Eisenberg elastic link equilibrium experimental exponential fibres fibrillar flight muscle filaments formulation frequency full isometric tension glycerol-extracted half-sarcomere Hill's model Huxley and Simmons Huxley's hydrolysis insect fibrillar flight insect flight muscle insect muscle interaction ionic strength Jewell and Wilkie k₁ k₂ kg/cm² kinetics length changes Lethocerus Lymn and Taylor measured mechanical monomers msec myosin ATPase myosin molecule obtained oscillation phosphate Podolsky and Nolan properties proteins rate constant reaction relaxed muscle release response Rüegg S₁ sarcomere sarcomere lengths sec-¹ semitendinosus muscle shortening shown in Fig sinusoidal steady-state step change step decrease step length-change structure suggested T₁ and T₂ Thorson and White time-course tropomyosin troponin two-element model velocity vertebrate muscle vertebrate striated muscle White and Thorson zero